Brand Name

Hyzaar DS {Merck Frosst}

Generic Name

losartan and hydrochlorothiazide ( loe SAR tan and HYE droe KLOR oh THYE a zide)

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Drug Guide

The information contained in the following drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.

What is Hyzaar DS?

Hyzaar DS is a medication to treat hypertension, or high blood pressure in adults. Hyzaar DS may be prescribed to keep your blood vessels from narrowing, which helps to lower your blood pressure and improve your blood flow. You may be given Hyzaar DS to help to lower your risk of stroke if you have heart disease.

Hyzaar DS may also be used for purposes not described in this medication guide.

Key Facts About Hyzaar DS

Hyzaar DS is an angiotensin II receptor antagonist, losartan, which means that it helps your blood vessels from narrowing, which lowers your blood pressure and improves your blood flow.

Hydrochlorothiazide, which is part of Hyzaar DS, is a thiazide diuretic, or water pill, that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Hyzaar DS is in FDA pregnancy category D. You should not use Hyzaar DS if you are pregnant. If you become pregnant while taking Hyzaar DS you should stop taking this medication and contact your doctor right away. Hyzaar DS may cause injury or death to an unborn baby if taken during your second or third trimester. You should be sure to use effective birth control while taking Hyzaar DS.

While you are taking Hyzaar DS you should not drink alcohol. Because drinking alcohol can further lower your blood pressure you may experience an increase in certain side effects of Hyzaar DS if you drink while taking it.

Unless your doctor has advised you to do so, you should not use potassium supplements or salt substitutes while you are taking Hyzaar DS

Continue to use Hyzaar DS as your doctor has directed, and be sure to get your blood pressure checked regularly.

Tell your doctor right away if you have ongoing vomiting or diarrhea, or if you are sweating more than usual while you are taking Hyzaar DS. It is easy to become dehydrated become dehydrated while taking Hyzaar DS, which can lead to extremely low blood pressure or a serious electrolyte imbalance.

Hyzaar DS may cause a condition which results in the breakdown of skeletal muscle tissue, and can lead to kidney failure. You should call your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, and especially if you also have a fever, exhaustion and dark colored urine.

Before You Take Hyzaar DS

If you are allergic to hydrochlorothiazide or losartan, you should not take Hyzaar DS.

If you are pregnant, think you may be pregnant, or are breastfeeding you should not take Hyzaar DS.

You should inform your doctor if you have liver disease, kidney disease, or congestive heart failure before taking Hyzaar DS.

If you suffer from asthma, glaucoma, gout or you should tell your doctor before starting treatment with Hyzaar DS.

Let your doctor know if low or high levels of potassium in your blood, diabetes, an allergy to sulfa drugs or penicillin or are unable to urinate before starting treatment with Hyzaar DS.

Until you know how you will react to Hyzaar DS you should avoid getting up too fast from a lying or sitting position, as you may experience dizziness. Be sure to get up slowly and steady yourself to prevent a fall, especially when you first begin your treatment with Hyzaar DS.

You need to be aware that certain conditions can cause low blood pressure, and make the effects of Hyzaar DS more pronounced for you. Tell your doctor right away if you experience diarrhea, heart disease, intense sweating, vomiting, dialysis, or if you are on a low salt diet or taking diuretics (water pills).

Hyzaar DS Drug Interactions

You should inform your doctor if you are taking any of the following:

• aspirin
• barbiturates like phenobarbital (Luminal, Solfoton)
• blood pressure medications
• celecoxib (Celebrex)
• cholestyramine (Prevalite, Questran)
• colestipol (Colestid)
• diabetes medication (oral) or insulin
• diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze)
• diuretics or water pills like amiloride (Midamor), bumetanide (Bumex), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar DS, Lopressor HCT, Vasoretic, Zestoretic), spironolactone (Aldactone) and torsemide (Demadex)
• ibuprofen (Advil, Motrin)
• indomethacin (Indocin), meloxicam (Mobic)
• lithium (Eskalith, Lithobid, Lithonate)
• meloxicam (Mobic)
• muscle relaxers suchlike baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), methocarbamol (Robaxin) and tizanidine (Zanaflex)
• naproxen (Aleve, Naprosyn, Naprelan, Treximet)
• narcotic pain medications like codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), oxycodone (OxyContin, Combunox, Roxicodone, Percocet), fentanyl (Abstral, Actiq, Fentora, Duragesic, Ionsys, Lazanda, Onsolis), methadone (Methadose, Dolophine) and morphine (Kadian, MS Contin, Oramorph)
• rifampin (Rifadin, Rimactane, Rifater)
• steroids (prednisone)

Other drugs you take that are not listed may interact with Hyzaar DS. You should tell your doctor about all of the medications you use. This includes prescription drugs, vitamins, supplements and herbal products, and over the counter medications. You should not begin taking a new medication without telling your doctor first.

Directions for Taking Hyzaar DS

You should take Hyzaar DS exactly your doctor has told you to. It is important that you do not take Hyzaar DS in larger or smaller amounts, or for longer or shorter than recommended. Follow the directions on your prescription label and follow any dose changes carefully if your doctor instructs you to change your dose.

Hyzaar DS should be taken at the same time every day, and with a full ( 8oz) glass of water.

Hyzaar DS can be taken with or without food.

You may need to take Hyzaar DS on a long-term basis for the treatment of high blood pressure. It is important that you follow up with your doctor on a regular basis to be sure that Hyzaar DS is helping your condition and not causing you to have any adverse or harmful effects.

Hyzaar DS should be stored at room temperature, and away from both moisture and heat.

If you miss a dose of Hyzaar DS you should attempt to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, or if your next dose is less than 12 hours away you should skip the dose you missed.

Hyzaar DS Side Effects

If you experience any of the following adverse effects you should stop taking Hyzaar DS and seek emergency medical help immediately.

• allergic reaction including hives, swelling in your face, lips, throat or tongue and trouble breathing
• appetite loss
• confusion
• drowsiness
• easy bruising
• high potassium symptoms, such as a slow heart rate, weak pulse, muscle weakness, or a tingly feeling
• increased thirst
• jaundice
• feeling faint or lightheadedness with pale skin
• fast or pounding heartbeats
• mood changes
• nausea
• swelling and rapid weight gain
• unexplained muscle pain, tenderness or weakness alongside a fever, exhaustion and dark colored urine
• urinating less than normal or not at all
• vision problems or eye pain
• vomiting

Less serious side effects of Hyzaar DS may include:

• back pain
• cold symptoms like a stuffy nose or sore throat
• dizziness
• dry cough
• exhaustion
• stomach pain

It should be noted that this is not a complete list of possible side effects of Hyzaar DS. You should contact your physician for a complete list and medical advice regarding these effects.

Hyzaar DS Description and Dosing

Hyzaar DS is available as a 100mg/25 mg tablet. The tablet is light yellow, oval-shaped, film-coated, with the code “747” on one side and plain on the other side.

If you suspect that you have overdosed with Hyzaar DS you should seek emergency help immediately.

Ingredients in Hyzaar DS

Hyzaar DS is available for oral administration and contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide. The inactive ingredients are hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, quinoline yellow aluminum lake or D&C Yellow No. 10 Aluminum Lake, and titanium dioxide. This medication may contain carnauba wax.

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The information contained in this drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.