Solodyn (minocycline)

Search by Drug or Product Name

Brand Name

Solodyn {Medicis}

Generic Name

minocycline, pronounced mye no SYE kleen


What is Solodyn?

Solodyn is an antibiotic that treats pimples and non-nodular inflammatory lesions, or red bumps, that occur in people with moderate to severe acne vulgaris. As a tetracycline antibiotic, Solodyn is approved to treat people ages 12 and older. You should not take Solodyn to treat acne that is not inflammatory, or not red looking.

Solodyn may also be used for conditions that are not described in this medication guide.


Key Facts About Solodyn

Solodyn can cause a permanent yellowing or graying of the teeth in children ages eight (8) and younger. You should not give Solodyn to a child under age 12.

Solodyn is in FDA pregnancy category D. Solodyn should not be taken if you are pregnant, as it can cause harm and a permanent tooth discoloration in your child. You should tell your doctor if you are pregnant, or if you plan to become pregnant before you start to take Solodyn. You should not use Solodyn without telling your doctor if you are breast-feeding a baby, as Solodyn passes into breast milk and can cause permanent tooth discoloration and affect your baby’s tooth and bone development.

Solodyn may cause diarrhea during treatment. This may be a side effect or the sign of a possible new infection. If you have diarrhea that is watery or bloody, you should stop taking Solodyn right away and call your doctor. Do not use any anti-diarrhea medications unless your doctor tells you to.

You should take care to wear an SPF 30 or higher when outdoors, and avoid direct sunlight and tanning beds. Solodyn can cause you to be more sensitive to the effects of the sun and burn more easily.

Take care when doing anything that requires you to be alert, such as driving, while taking Solodyn. This medication may affect your thinking and reaction time.


Before You Take Solodyn

You should not use Solodyn if you are allergic to minocycline or other tetracycline antibiotics like demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin) or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Tell your doctor if you also using a penicillin antibiotic like amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill) or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen) before taking Solodyn.

Let your doctor know if you have liver disease, kidney disease or asthma before starting treatment with Solodyn.

Tell your doctor if you have a sulfite allergy before taking Solodyn.

Solodyn may make your birth control pills less effective. You should talk to your doctor about birth control options while you are being treated with Solodyn.

You should not take any calcium supplements, multivitamins, iron supplements, antacids, or laxatives within 2 hours before or 2 hours after taking Solodyn, as these products may make this medication less effective.


Solodyn Drug Interactions

You should inform your doctor if you are taking any of the following:

  • acetaminophen (Tylenol)
  • antibiotics
  • antifungal medications like itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig) and voriconazole (Vfend)
  • acetaminophen (Tylenol)
  • cholesterol medications like niacin (Advicor, Niaspan, Niacor, Simcor, Slo Niacin), atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor, Simcor, Vytorin)
  • heart or blood pressure medications like benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril) and quinapril (Accupril), ramipril (Altace)
  • isotretinoin (Accutane, Amnesteem, Claravis, Sotret)
  • methotrexate (Rheumatrex, Trexall)
  • migraine medications like ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal) and methylergonovine (Methergine)
  • NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin) and meloxicam (Mobic)
  • warfarin (Coumadin, Jantoven)

Other drugs you take that are not listed may interact with Solodyn. You should tell your doctor about all of the medications you use. This includes prescription drugs, vitamins, supplements and herbal products, and over the counter medications. You should not begin taking a new medication without telling your doctor first.


Directions for Taking Solodyn

You should take Solodyn exactly as your doctor has prescribed you to. Do not use Solodyn in larger or smaller amounts, or for shorter or longer than recommended. Follow the directions on your prescription label exactly.

You can take Solodyn with or without food. If you are concerned about getting an ulcer or irritation in your esophagus you should take Solodyn with food.

You should take Solodyn with a full (8 oz.) glass of water.

Do not break, chew or crush the Solodyn tablet, swallow it whole.

Solodyn can cause you to have unusual results with certain urine tests. Let any doctor know that you seeing know you are taking Solodyn.

You should store Solodyn at room temperature, and away from heat, light and moisture.

Be sure to dispose of expired Solodyn after the expiration date, as using it can cause serious kidney damage.

If you need to have surgery you may be told by your doctor to stop taking Solodyn for a period of time. Make sure that any doctor, surgeon or dentist who treats you knows that you are taking Solodyn.

If you miss a dose of Solodyn you should attempt to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose do not take the missed dose in addition to your regular dose.



Solodyn Side Effects

If you experience any of the following adverse effects you should stop taking Solodyn and seek medical help immediately:

  • allergic reaction that includes breathing difficulties, hives and swelling of your face, lips, throat or tongue
  • bleeding that is unusual, like from places such as your nose or throat and red or purple pinpoint spots under your skin
  • chest pain with coughing and wheezing
  • confusion
  • diarrhea that is watery or bloody and stomach cramps
  • ear ringing
  • eye pain or vision problems
  • fever with muscle pain, swollen glands and joint pain and swelling
  • flu symptoms
  • headache
  • irregular heartbeat
  • jaundice with upper stomach pain and appetite loss
  • seizures
  • severe skin reaction and fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) that causes blistering and peeling
  • skin that is pale or yellowed
  • sores in your mouth and throat
  • swelling and weight gain
  • unusual thoughts or behavior and mood changes
  • urinating less than usual or not at all
  • urination that is dark colored
  • vomiting
  • weakness

Less serious Solodyn side effects may include:

  • diarrhea (mild) and stomach pain
  • dizziness and spinning sensation
  • gum discoloration
  • joint or muscle pain
  • nail discoloration
  • nausea (mild)
  • skin rash and itching (mild)
  • swollen tongue
  • tiredness
  • vaginal itching or discharge

It should be noted that this is not a complete list of possible side effects of Solodyn. You should contact your physician for a complete list and medical advice regarding these effects.


Solodyn Description and Dosing

Solodyn is available as aqueous film coated tablets in dosages of 45 mg, 65 mg, 90 mg, 115 mg and 135 mg minocycline.

The 45 mg extended release tablets are gray, unscored, coated, and debossed with “DYN-045” on one side.

The 65 mg extended release tablets are blue, unscored, coated, and debossed with “DYN-065” on one side.

The 90 mg extended release tablets are yellow, unscored, coated, and debossed with “DYN-090” on one side.

The 115 mg extended release tablets are green, unscored, coated, and debossed with “DYN-115” on one side.

The 135 mg extended release tablets are pinkish-orange-brown, unscored, coated, and debossed with “DYN-135” on one side.

Solodyn dosages vary for each individual based on their age, condition and situation. Your doctor will tell you the right dose of Solodyn for you to take. Do not change or alter your Solodyn dose without talking to your doctor first.

If you suspect that you have overdosed with the Solodyn you should seek emergency help immediately.

Ingredients in Solodyn: The active ingredient in Solodyn is minocycline hydrochloride. Inactive ingredients include lactose monohydrate, hypromellose type 2910 USP, magnesium stearate, colloidal silicon dioxide, and carnauba wax. The 45 mg tablets also contain opadry II gray which contains: lactose monohydrate , hypromellose type 2910 USP, titanium dioxide USP, triacetin USP, and iron oxide black JPE. The 65 mg tablets also contain opadry II blue which contains: hypromellose type 2910 USP, lactose monohydrate, FD&C Blue #1, polyethylene glycol 3350, FD&C Blue #2, titanium dioxide USP, triacetin USP, and D&C Yellow #10. The 90 mg tablets also contain opadry II yellow which contains: hypromellose type 2910 USP, lactose monohydrate , titanium dioxide USP, iron oxide yellow , polyethylene glycol 3350 , and triacetin USP. The 115 mg tablets also contain opadry II green which contains: hypromellose type 2910 USP, lactose monohydrate, D&C yellow #10, triacetin USP, FD&C Blue #1, titanium dioxide USP, and FD&C Blue #2. The 135 mg tablets also contain opadry II pink which contains: hypromellose type 2910 USP, lactose monohydrate , titanium dioxide USP, polyethylene glycol 3350 , iron oxide red , and triacetin USP.

Back to Top


The information contained in this drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.