Brand Name

Zyloprim {Prometheus Laboratories}
Also known as Zyloric

Generic Name

allopurinol, pronounced al oh PURE i nole

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Drug Guide

The information contained in the following drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.

What is Zyloprim?

Zyloprim is a medication used to treat gout, kidney stones, and to decrease levels of uric acid if you are receiving certain types of cancer treatment. This medication works by reducing the production of uric acid in your body. Zyloprim may also be used for reasons not stated in this medication guide.

Key Facts About Zyloprim

Zyloprim needs to be taken with a full glass of water (8 oz.), as well as 8 to 10 full glasses of fluid daily to prevent kidney stones from forming.

Zyloprim can cause a serious skin rash, and you must tell your doctor immediately if you have a rash, even if it is mild.

You should not drink alcohol while taking Zyloprim, as it may worsen your condition.

Be aware that Zyloprim may impair your reactions or thinking. You should be careful when driving or doing anything which requires you to be alert, especially when you first start Zyloprim.

Tell your doctor if you are pregnant or plan to become pregnant. Zyloprim is in FDA pregnancy category C. If is not known if Zyloprim can affect your unborn baby. Zyloprim is known to pass into breast milk. You should talk to your doctor if you are breastfeeding and prescribed this medication.

Before You Take Zyloprim

If you are allergic to allopurinolyou should not take Zyloprim.

Tell your doctor if you a history of heart disease, congestive heart failure or high blood pressure before starting treatment with Zyloprim.

If you have a history of liver or kidney disease, diabetes, or if you are undergoing chemotherapy you should tell your doctor before taking Zyloprim.

Zyloprim may lower your blood cells which help your body to fight infection. Take care to avoid being around people who are ill while you are taking Zyloprim.

Zyloprim Drug Interactions

You should inform your doctor if you are taking any of the following:

• antibiotics like clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole) and telithromycin (Ketek)
• azathioprine (Imuran)
• blood thinners like warfarin (Coumadin or Jantoven)
• chlorpropamide (Diabinese)
• cyclosporine (Gengraf, Sandimmune, Neoral)
• diuretics (water pills)
• mercaptopurine (Purinethol)
• organ transplant rejection prevention medications like such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) and tacrolimus (Prograf)

Other drugs you take that are not listed may interact with Zyloprim. You should tell your doctor about all of the medications you use. This includes prescription drugs, vitamins, supplements and herbal products, and over the counter medications. You should not begin taking a new medication without telling your doctor first.

Directions for Taking Zyloprim

Zyloprim may be taken with or without food.

You must take Zyloprim with a full (8 oz.) glass of water.

You should drink 8-10 glasses of fluids daily while taking this medication.

You should take Zyloprim exactly as prescribed by your doctor. Do not take Zyloprim in larger or smaller amounts, or for shorter or longer than recommended. Follow the directions on your prescription label.

Your doctor may prescribe a special diet for you to follow while taking this medication. Take care to follow your doctor’s instructions exactly.

Zyloprim may lower your blood cells which help your body to fight infection. Take care to avoid being around people who are ill while you are taking this medication.

You may experience gout attacks more often when you first start taking this medication. Tell your doctor if your symptoms don’t improve within a few months of taking Zyloprim. Your doctor may prescribe other medications to treat gout while you are taking Zyloprim.

Zyloprim needs to be stored at room temperature, and away from light, moisture and heat. Keep your bottle tightly closed when you are not using it.

If you miss a dose of Zyloprim you should attempt to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose do not take the missed dose in addition to your regular dose.

Zyloprim Side Effects

If you experience any of the following adverse effects you should stop taking Zyloprim and seek emergency medical help immediately:

• allergic reactions such as breathing difficulties, hives or swelling of your face, lips, throat or tongue
• appetite loss with nausea, itching, upper stomach pain, nausea and jaundice
• bruising or bleeding easily, including red or purple pinpoint spots under your skin
• clay colored stools
• fever with a sore throat, headache and a blistering skin rash
• flu symptoms
• joint pain
• numbness or tingling feeling with pain or muscle weakness
• rash on your skin, even if it is mild
• urinating less than normal or not at all
• darkened urine
• urine with blood in it

Less serious side effects of Zyloprim may include:

• mild diarrhea
• drowsiness
• headache
• muscle pain
• taste changes, or changes in your sense of taste
• mild vomiting

It should be noted that this is not a complete list of possible side effects of Zyloprim. You should contact your physician for a complete list and medical advice regarding these effects.

Zyloprim Description and Dosing

Zyloprim is available as 100 mg and 300 mg tablets, which are scored. The 100 mg tablets are white, flat cylindrical tablets imprinted with “Zyloprim 100” on a raised hexagon. The 300 mg tablets are peach, flat cylindrical tablets imprinted with “Zyloprim 300” on a raised hexagon.

You should consult your doctor for specific dosing pertaining to you. Do not attempt to alter or change your dose without your physician’s consent.

If you suspect that you have overdosed with Zyloprim you should seek emergency help immediately.

Ingredients in Zyloprim

The primary active ingredient in Zyloprim is allopurinol. Inactive ingredients include corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone.

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The information contained in this drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.